Certified Neuroscience Registered Nurse (CNRN) Practice Exam

Which of the following organs is primarily responsible for the production of antibodies?

1. Liver

2. Spleen

3. Kidney

4. Bone marrow

The correct answer is: Spleen

The spleen plays a significant role in the immune system, but it is not the primary site for antibody production. Antibodies, which are crucial for the immune response, are mainly produced by B cells that mature in the bone marrow. Once these B cells encounter their specific antigen, they can differentiate into plasma cells, which are responsible for producing and secreting antibodies into the bloodstream. The bone marrow is where B cells develop and become activated, making it the primary organ accountable for antibody production. Other organs like the liver and kidney have different, vital functions in the body, but they are not directly responsible for the production of antibodies. The liver contributes to various metabolic processes and detoxification, while the kidneys are involved in filtration and fluid balance—activities that do not include the production of antibodies. Therefore, the correct response emphasizes the role of the bone marrow in the production of antibodies, making it the right answer in this context.