Certified Neuroscience Registered Nurse (CNRN) Practice Exam

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Which drug can be administered to avoid hepatotoxicity when taking Tylenol?

Ibuprofen
Acetylcysteine
Asprin
Meloxicam

The correct answer is: Acetylcysteine

Acetylcysteine is the correct choice for preventing hepatotoxicity when taking Tylenol, which is the brand name for acetaminophen. The liver metabolizes acetaminophen, and in cases of overdose, it can lead to the depletion of glutathione, a key antioxidant in the liver that helps to neutralize toxic metabolites. Acetylcysteine acts as a precursor to glutathione and can replenish its levels, effectively providing a protective effect against liver damage. Administering acetylcysteine within a certain window following an acetaminophen overdose can significantly reduce the risk of hepatotoxicity. Other drugs listed do not offer the same preventative action against acetaminophen-induced liver damage. For example, ibuprofen and meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs) and do not have any protective effects specific to the hepatotoxic risks associated with acetaminophen. Similarly, aspirin is not indicated in this context; it may even exacerbate liver issues in certain situations. Thus, acetylcysteine is specifically recognized in clinical practice for its role in managing acetaminophen toxicity.