Certified Neuroscience Registered Nurse (CNRN) Practice Exam

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What is the recommended dose of dexamethasone for PONV at induction?

  1. 4 mg IV

  2. 8 mg IV

  3. 10 mg IV

  4. 12 mg IV

The correct answer is: 8 mg IV

The recommended dose of dexamethasone for the prevention of postoperative nausea and vomiting (PONV) at induction is typically established at 4 mg administered intravenously. This dosage has been shown to be effective in various studies aimed at reducing the incidence of nausea and vomiting following surgery. Utilizing a dose of 8 mg may lead to increased side effects without providing a significant increase in efficacy compared to 4 mg. The goal in administering dexamethasone is to provide adequate antiemetic coverage while minimizing potential adverse effects that can arise from higher doses. Thus, the standard of care and current clinical guidelines generally support the 4 mg IV dosing as both effective and safe for managing PONV during the induction phase.