Certified Neuroscience Registered Nurse (CNRN) Practice Exam

What is the preferred method of administration for Phenergan due to infiltration risks?

1. Intravenous

2. Oral

3. Topical

4. Deep IM route

The correct answer is: Deep IM route

Phenergan, or promethazine, has specific administration routes that are preferred due to its potential side effects and risks associated with certain methods. The deep intramuscular (IM) route is preferred because it minimizes the risk of infiltration and associated complications like tissue necrosis that can occur with intravenous administration. When given intramuscularly in the deep tissue, the medication is absorbed into systemic circulation more slowly than with intravenous injection, which can reduce the risk of adverse effects at the injection site while still effectively providing the therapeutic benefits intended. This route allows the nurse to ensure that the medication is delivered safely and effectively while protecting the patient from the risks associated with other methods, such as intravenous infiltration. Oral administration is certainly an option for Phenergan; however, it may not be suitable for patients who cannot take medications orally or require immediate relief for nausea or vomiting. Topical administration is not applicable for this medication as it does not have a transdermal formulation or use case in this context. While the intravenous route is effective, it brings the risk of infiltration. Thus, the deep IM route is the safest and most effective choice in this scenario.