Certified Neuroscience Registered Nurse (CNRN) Practice Exam

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Vitamin B12 deficiency may be caused by malabsorption due to which of the following?

  1. Chronic renal failure

  2. Pernicious anemia

  3. Hemorrhagic disease

  4. Aplastic anemia

The correct answer is: Pernicious anemia

Vitamin B12 deficiency can occur due to malabsorption, and one of the primary causes of this is pernicious anemia. This condition is characterized by a lack of intrinsic factor, a protein produced by the stomach that is essential for the absorption of vitamin B12 in the intestine. Without adequate intrinsic factor, even if vitamin B12 is consumed through diet or supplements, the body cannot effectively absorb it, leading to a deficiency. In contrast, chronic renal failure primarily affects the kidneys and does not directly impact the absorption of vitamin B12. Hemorrhagic disease involves bleeding disorders, which would not typically influence vitamin absorption. Aplastic anemia involves the failure of blood cell production in the bone marrow and is not linked to the absorption of vitamin B12. Therefore, pernicious anemia stands out as the correct answer in the context of malabsorption-related vitamin B12 deficiency.

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