Certified Neuroscience Registered Nurse (CNRN) Practice Exam

The best pharmacologic approach to symptoms of restless leg syndrome (RLS) usually involves what strategy?

1. Continuous medication therapy

2. Rest and relaxation techniques

3. Cyclic deployment of various classes of medications

4. High doses of opioids

The correct answer is: Cyclic deployment of various classes of medications

The best pharmacologic approach to managing symptoms of restless leg syndrome (RLS) often involves cyclic deployment of various classes of medications. This strategy is effective as it allows for the optimization of treatment responses while minimizing the potential for tolerance and side effects associated with long-term use of a single medication. RLS is characterized by uncomfortable sensations in the legs and an overwhelming urge to move, often exacerbated by inactivity. As the condition can vary in severity and respond differently to treatments, employing a cyclic approach—switching between different classes of medications—can provide relief and manage symptoms more effectively over time. Using various medications can also help address the different aspects of RLS, as certain drugs may target underlying neurotransmitter imbalances or other factors contributing to the symptoms. This diversification in treatment can lead to better overall management of the syndrome. Continuous medication therapy might lead to tolerance, where patients find that their symptoms return as the effectiveness of the medication decreases over time. Meanwhile, high doses of opioids are generally not recommended as a primary treatment for RLS due to the risk of dependence and side effects. Rest and relaxation techniques, while potentially beneficial as adjunctive therapies, do not typically provide sufficient relief on their own to manage the symptoms effectively.